Tamoxifen Undergoes Optimization Essay -- Medical Drug

Tamoxifen Undergoes Optimization Abstract Computer programs like GaussView and Gaussian 03W are some of the advanced tools that can be used by scientists to design and optimize new designed drug. Using the exact same tools as scientists today, I am going to take a known drug, Tamoxifen, and create few analogs similar to its structure. Before I can create some analogs in GaussView, I am going to study and examine the structure of Tamoxifen to understand the chemistry that involves in this structure. For example, the bonds between molecules and the interactions between the drug and estrogen receptor complex site. After I design an analog of Tamoxifen, I will then use the Gaussian 03W program to optimize the analog. As for the last step in determining if an analog is a good candidate for a new designed drug, I am going to use a special computer program called OpenEye Software to help me make that prediction. Introduction Breast Cancer is the most common type of cancer known among women in the US. It is the second-leading cause of cancer-related deaths. More than 180,000 women are diagnosed with breast cancer each year. In 2006, out of all of these women, 40,000 died. Although breast cancer mainly affects women, data shows that men can also be affected as well; each year more than 1,000 men are diagnosed with breast cancer 3. This information shows that cancer can affect anyone regardless of an individual’s gender, ethnicity, etc. It is important that everyone knows about breast cancer and helps friends or family members with breast cancer to find way to diagnose it. In nowadays, scientists are learning more about cancer and are exploring new ways to prevent, detect, diagnose, and treat this deadly disease 1. .. ...c., 1997. 3. Corey, E. J., Barbara Czako, and Laszlo Kurti. Molecules and medicine. New Jersey: John Wiley &Sons, Inc., 2007. 4. Jordan, V., ed. Long-Term Tamoxifen Treatment for Breast Cancer. Wisconsin: The University of Wisconsin Press, 1994. 5. Oxford University Press. "Figure 18.44: Tamoxifen." Online Resource Centre. 29 Jul. 2008. tamoxifen.jpg>. 6. Wikipedia. "Tamoxifen." Wikipedia. 29 Jul. 2008. . 7. Wiseman, Helen. Tamoxifen-Molecular Basis of Use in Cancer Treatment and Prevention. England: John Wiley &Sons Ltd, 1994. 8. Nolte, RT. "Crystal structure of Estrogen Related Reecptor-3 (ERR-gamma) ligand binding domaind with tamoxifen analog GSK5182." Protein Data Bank. 29 Jul. 2008. .

Elizabeth Gaskell Essay

After Helen died things didn’t get much better. The farm workers started to look down upon him and ‘hardy waited till my father’s back was turned rated the stepson’, even his own brother looks down upon him unintentionally ‘I sometimes repeated the disparaging words I heard†¦ Without fully understanding their meaning’. This makes us feel a lot of sympathy towards Gregory and we feel sorry for him. There seems to be a close link between Gregory life and his Mother life. No matter what happens, they try to make the best of things and get on with it. Preston maintains and feeds his hatred of Gregory instead of repressing it; he ‘cherished his feeling of alienation’ he had from Gregory. He lived the save type of life as her, one of suffering and one full of sorrow, death seems like a better place for him he is along side the one and only person who loved him. Preston holds a grudge on Gregory right from the very start. But we must admire Gregory for not begrudging him or any other person who treats him badly even if they have just been nasty to him, he would ‘do a kind turn for anyone, even if they had been scolding him’. He is parallel to his mother. This helps us to warm to him as a character. Gregory is stoical and endures things with uncomplaining patience which’s helps us to admire him. Gaskell creates a character that speaks highly of Gregory. Nearly every one of the farm workers has a bad thing to say about him apart from old Adam. Gregory is sent out onto the hills as a Shepard with along with Adam who trains him. Adam is the only person apart from Gregory’s mother who has not got a bad word to say about him, but indeed praises him. This is likely to the fact that Adam was ‘almost the first person who had a good opinion of Gregory’ and even told this to his boss, Preston. Later in the story when the narrator goes missing, Gregory goes out in the thick snow to look for his half brother risking in his own life and not even thinking about it. This also seems parallel to Helen who had done similar for Gregory by putting Gregory first and looking out for him without even thinking about it. When Gregory manages to find the narrator, Gaskell makes us feel even more admiration for him. In the freezing snow, he gives his brother the Maud (woollen shawl) that he is wearing so that the narrator can stay just a little bit warmer. This makes us warm to Gregory, because of the fact he is suffering for the sake of his brother. Gaskell evokes admiration from the readers, Gregory died for his brother, and someone he barely knew and did not even complain about it. Gaskell creates a character that many of the readers may take a disliking to and manages to get ambivalent responses from the readers. Preston is described as being ‘an old bachelor†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦ long past forty’ and ‘one of the wealthiest farmers thereabouts†. Helen agrees to marry him solely on that the fact that he ‘promised to take good charge of her boy, and let him want for nothing, neither in way of keep nor in education’. This almost seems a purely business agreement. He uses Gregory as an excuse in order to marry Helen. Gaskell makes our response to Preston more complex than any other of the characters; she manages to get a complicated reaction to Preston through a short story. With the other main characters, it is obvious how Gaskell is trying to portray them but it is not obvious in Prestons case. We are suspicious of him at the start. At the start of â€Å"The Half Brothers† Preston is made out to be a horrible man, but by the end of the story our feelings have softened against him. He is very impatient, he does not wait for Helen to love him ‘Perhaps love would have come in time’. Preston begrudges Gregory as child for the attention he receives from Helen. He is jealous of him, and cannot stand Helen loving Gregory more than him. Preston is dehumanised. He does not love Gregory at all, but hates him. But later on we see that Preston is humanised, ‘glad and proud his son was born’. He becomes ‘sorry for his poor wife’s state’, but still blames it on Gregory and holds him responsible for Helens death even though it is his own fault for arguing with her. After Helens death Preston honours the agreement for which they were married under, to look after Gregory. But he makes no attempt to love him, only to give him material things that money can buy, nothing emotional. Even Preston is hurting Gregory’s dog, just because it belongs to Gregory, he has a real dislike to anything that Gregory owns or anything to do with. Even Preston’s own son thinks he is to hard on Gregory ‘I believe that my father cherished his feeling of alienation to my brother as a duty, than strove to repress it’ But towards the end of â€Å"The Half brothers† Gaskell makes us feel differently towards him. There is a sense of deep regret from Preston on his deathbed about the way that he treated Gregory throughout his life â€Å"God forgive me my hardness of heart towards the fatherless child! † After his death he knows that Helen loved Gregory more and so as a sign of repentance had ‘desired that he might lie at the foot of the grave, in which, by his desire, poor Gregory had been laid with our mother. ‘ Preston is very grateful and thankful to Gregory for saving his sons life â€Å"I would have given him half my land†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦ I would have blessed him as my son†. He even tries to be kind to the dog, but it won’t let him near it. Gaskell is very good at creating and holding suspense for long periods of time through the story. At the start of the story, just after Helen’s husband dies suspense starts to build up as we become worried about Helen’s future and continues to hold the suspense until she marries Preston. When the narrators gets lost, the fact that ‘night came on quicker’ makes us feel unnerved that night is overtaking him and that he may get stuck there all night. An eerie atmosphere is created which intensifies the suspense even further ‘some wild boggy moor†¦ ‘ Tautology is used to emphasis how dark it and adds to the suspense ‘noiseless expansion of black darkness’. Gaskell’s use of language also helps to create suspense. ‘Suddenly the air was filled†¦ ‘, suddenly is placed at the beginning of the sentence to show how quickly and unexpectedly the snow fell. We start to become worried for the narrator and the suspense is built up even further by the emotional language used ‘I shouted – terrible, wild shouts for bare life’ and ‘choked with tears†¦ desolate, helpless death I was to die’ – shows how extreme the situation is, how isolated and lonely the narrator must have felt. The narrator starts to give up hope and we start to feel very sorry for him and then just as all hope is gone, lassie comes to his rescue, we now see that he saved and is going to get home safely as he has been found. Just as soon as we feel relief that he has been found, there poses as even bigger problem, instead of one person being lost, there are two – the suspense is deepened even further than before. As the two try to find their way home, it is apparent that they are not going to get home and could die out there. All of this creates suspense and makes the reader want to read on to see if the pair gets home all right. The suspense reaches it climax near the end of the story. When the narrator determined to sleep and doesn’t care if he dies. When the pair realise that they can go no further, they stop as a last resort – they know that they are going to die and sent lassie back to get help. The suspense is mounted to see whether or not lassie can get back to the ranch before the pair die of the cold. Then the narrator ‘fell asleep’. We think is the end, he has fallen asleep he will die. But then a sense of relief comes over us when we find that the narrator has been found just time and survives, but Gregory is not so lucky. Through out the story â€Å"The Half Brothers† Gaskell evokes and manipulates many of our feelings. But some readers, including myself find that some of the story mawkish and trying to push at our emotional buttons in an unsophisticated way. Gaskell style of writing helps to manipulate our feelings. The way she portrays Helen’s and Gregory’s lives makes us feel a lot of sympathy towards them but we admire the way they put up with everything without complaining. She creates a character, which seems to be the bad guy of the story and evokes complex feelings for him from us. Some readers including myself may find that Preston is an horrid man and continue to think the same even when Gaskell tries to soften his image by saying that he has become ‘humanised’, but others may feel that he is a good man at heart and this is portrayed at the end of the story when he is deeply regretful. Gaskell is very good at creating suspense and makes us worried about the characters and makes us want to read on. So overall Gaskell is very good at manipulating our feelings.

Hiroshima Diary Essay

First of all, I would like to say that you have an overall good paper in my opinion. The first thing that I can suggest is a better hook. My attention wasn’t drawn into the paper. I suggest a quote by a scientist or other survivor, and/or a statistic – something that will make a reader think about the paper more. Another thing that I can recommend is to add a little bit more background on the two narratives, but just very brief (a couple sentences). Also I’d like to point out some things that you could use to improve your thesis. The essay is about â€Å"cause and effect† so it has to be mentioned in your thesis. Also mention the 2 things you will compare between the two stories so the reader has an idea where the paper will be going. Other things I noticed that sounded awkward are the way you used quotes. Introducing quotes is a better strategy than just using the quote as a sentence (paragraph 2) as it gives a better flow and gives a better explanation for your argument. Also in my opinion you could expand more on your analysis of both paragraphs and connect your argument to the thesis and to each other so you have a better evaluation of the discussed topic. There are several other small issues that I found. In paragraph 3 you used a long quote, which is 4+ lines, and it should be in a block format and indented. Also you used very short sentences such as, â€Å"Here are the quotes for the effect.† Using more complex sentences gives a better flow and a more professional look to your essay. You also had some good things in your essay. You provided very concise summary to inform a reader about the story and point out the most important information. You point. Also you have very good topic sentences introducing the argument of that paragraph. From your topic sentences I was able to know what they paragraph would be about, and you were consistent with it. After reading your essay and compared it to my own, I figured that I need to include a better summary. I do not give sufficient background information to be enough for my analysis. Junjie, you did a great job at providing accurate citations, great summary and good analysis. However, you could work on expanding your synthesis and evaluation of the argument in your body paragraph. Otherwise, good job.

Inflation Targeting

Inflation Targeting Free Online Research Papers In order to achieve price stability in New Zealand, the monetary policy Inflation Targeting was adopted in 1990. With the growth and success of this new strategy, Canada, the United Kingdom, Sweden, Spain and many other counties followed suit in the subsequent years ahead. Inflation targeting is an economic policy in which a monetary authority such as the European Central Bank publicly announces what they are going to do in regards hiring or lowering the inflation rate. They estimate a percentage such as 2 percent a year and make a target inflation rate, then attempt to move the actual inflation rate toward that rate. Through the use of interest rate changes and other monetary tools inflation targeting is possible. Although inflation targeting has many advantages, some countries for see the many disadvantages of low economic growth and too much rigidity. Many criticize the idea of inflation targeting and how there are disadvantages to this policy. An inflation target lacks the ability to send signals immediately to the public and then to the markets, therefore delaying signaling. The belief that inflation targeting imposes rigid rules on policymakers makes economics think there is too much rigidity. Low employment and the low growth in the economy is also a concern of some economists. Yet, the prime concern of inflation targeting does not solely focus on inflation and the potential for increased output fluctuations. Along side to the validity of these criticisms there are several advantages to inflation targeting. The stability between inflation and money is not the primary success of this policy. It is with the central bank increasing its accountability; the transparency of the policy associated with inflation targeting has made the central bank vastly accountable to the public and the government. The primary advantage of inflation targeting is keeping the inflation rate low. The countries that adopted inflation targeting have drastically reduced their rate of inflation and have kept it down till this day. By not focusing completely on inflation and keeping the inflation rate low, critics can see both sides of the advantages and disadvantages of inflation targeting. With over ten counties using this monetary policy of inflation targeting for now over twenty five years it is clear that advantages and disadvantages will arise and critics will have their say on what they think is best. Research Papers on Inflation TargetingThe Mechanics of Grading Grading SystemsAmerican Central Banking and OilDefinition of Export QuotasSexually Transmitted DiseasesInfluences of Socio-Economic Status of Married MalesA Marketing Analysis of the Fast-Food RestaurantThe Effects of Illegal ImmigrationGene One the Transition from Private to PublicBionic Assembly System: A New Concept of SelfAssess the importance of Nationalism 1815-1850 Europe

Euthanasia Death and Euthanasia Essay

Euthanasia Death and Euthanasia Essay Euthanasia: Death and Euthanasia Essay Research Essay – Euthanasia Euthanasia is a serious moral and ethical issue in today’s world. Rightly so. Approximately 1.2million people in the United States and about 564,600 Americans annually – more than 1,500 people per day are suffering from terminal illnesses (Growthhouse). However, most people think that euthanasia is murdering, even if they believe that suffering is a horrible thing. Being bed-ridden in pain because of a disease or sickness is completely horrifying. Interestingly, someone came up with an act that is known as â€Å"Euthanasia† which allows people to kill themselves due to pain or suffering. Often, it is confused with the term â€Å"assisted suicide† which means someone, normally a physician, voluntarily helps the patient to end his or her life. Euthanasia is the act of someone ending the life of a terminally ill person by injection or medical treatment. This is a topic that consists of countless opinions and much controversy as to whether euthanasia should b e legalized or not. Even though I have never known a person that has an incurable disease or sickness, if a loved one or I were diagnosed, for instance, with a terminal illness like cancer, I would definitely choose euthanasia as an option to end the suffering and pain in my life. If there were no other way to cure the disease and take away the agony, patients would not want to live a painful life and die a tormented death. Instead, being helped by someone to take away the pain sooner, even if that meant dying, would be a better option. Though some may not choose euthanasia or physician assisted suicide. At least, by having the right to choose euthanasia, one has hope of making the pain end. Therefore, I agree with the practice of euthanasia and strongly believe that everyone has the right to decide whether they want to end their own life or not. First of all, deciding to live or die should be a personal decision to be made by everyone. However, many people support legalizing Euthanasia. Author Sidney Hook is one of these people. In his article â€Å"In Defense of Voluntary Euthanasia,† he believes that â€Å"each one should be permitted to make his/ her choice especially when no one else is harmed by it† (Hook, 242-245). I strongly agree with his philosophy that people have the right to choose to live or die because I think people who live their lives enduring pain and suffering because of a sickness are already facing so much and, furthermore, they wouldn’t want to be a lifelong liability to their family. This question often arises: â€Å"Where do the sick people go when there is no medical help available and the disease in question is incurable? Are they expected to go on with their life until the pain kills them? That is absolutely brutal! If a patient has no hope to live a comfortable life any longe r because he is suffering from unbearable pain, why should the law or the patient’s family have the right to make the decision whether he/she should live or die? It should be the patient’s right to decide if they want to end their life by euthanasia. This may help the suffering patients to die a less painful death (Rottenberg, â€Å"You Live Your Life, I’ll Take Mine!†) and maybe end their own life with some happiness. Euthanasia should be seen as a ray of hope for a suffering person. Then again, it shouldn’t be perceived as an answer to every illness. Only a patient who is terminally ill or is suffering in extreme anguishing pain should have the right to choose if he prefers to end his life by the practice of euthanasia. It should not be determined by anyone else how long a person’s pain should continue. There should not be a law that denies someone the hope to put an end to his or her pain. How could there exist a law that states that euthanasia cannot be legal in any case? It is not right for other people, for instance, a doctor or an intellectual, to decide if it is immoral to practice euthanasia. They don’t understand the pain and suffering of the patient in such

Avogadros Number To Calculate Mass of a Single Atom

Avogadro's Number To Calculate Mass of a Single Atom Avogadros number is one of the most important constants used in chemistry. It is the number of particles in a single mole of a material, based on the number of atoms in exactly 12 grams of the isotope carbon-12. Although this number is a constant, its experimentally determined, so we use an approximate value of 6.022 x 1023. So, you know how many atoms are in a mole. Heres how to use the information to determine the mass of a single atom. Avogadro's Number Example Problem: Mass of a Single Atom Question: Calculate the mass in grams of a single carbon (C) atom. Solution To calculate the mass of a single atom, first look up the atomic mass of carbon from the periodic table.This number, 12.01, is the mass in grams of one mole of carbon. One mole of carbon is 6.022 x 1023 atoms of carbon (Avogadros number). This relation is then used to convert a carbon atom to grams by the ratio: mass of 1 atom / 1 atom mass of a mole of atoms / 6.022 x 1023 atoms Plug in the atomic mass of carbon to solve for the mass of 1 atom: mass of 1 atom mass of a mole of atoms / 6.022 x 1023 mass of 1 C atom 12.01 g / 6.022 x 1023 C atomsmass of 1 C atom 1.994 x 10-23 g Answer The mass of a single carbon atom is 1.994 x 10-23 g. Applying the Formula to Solve for Other Atoms and Molecules Although the problem was worked using carbon (the element upon which Avogadros number is based), you can use the same method to solve for the mass of an atom or molecule. If youre finding the mass of an atom of a different element, just use that elements atomic mass. If you want to use the relation to solve for the mass of a single molecule, theres an extra step. You need to add up the masses of all of the atoms in that one molecule and use them instead. Lets say, for example, you want to know the mass of a single atom of water. From the formula (H2O), you know there are two hydrogen atoms and one oxygen atom. You use the periodic table to look up the mass of each atom (H is 1.01 and O is 16.00). Forming a water molecule gives you a mass of: 1.01 1.01 16.00 18.02 grams per mole of water and you solve with: mass of 1 molecule mass of one mole of molecules / 6.022 x 1023 mass of 1 water molecule 18.02 grams per mole / 6.022 x 1023 molecules per mole mass of 1 water molecule 2.992 x 10-23 grams

Course Project - Report Assignment Example | Topics and Well Written Essays - 2000 words

Course Project - Report - Assignment Example energy needs. 4) To give a personal opinion regarding the hydraulic fracturing process and the laws that should be instituted. INTRODUCTION Hydraulic fracturing refers to a process used to extract gas or oil from beneath the earth’s surface by pumping liquid at high pressure to the subsurface rocks. The pressure in this liquid is enough to fracture the rocks thus establishing interconnected networks of fractures that are then used as pores for the oil and gas to move to the bored well. It is from this well that the final extraction is done. The process has been so far effective and efficient in so far as extraction of oil and natural gas is concerned (Wilber, 2012). Nonetheless, various legal and environmental issues have been raised regarding the process. Its impacts on the environment have not augured well with a majority of the environmentalists. Similarly, various legal concerns have been raised and they vary from one state to the next. In this paper, I seek to present a r eport on the hydraulic fracturing process, the legal and environmental issues, as well as offer some of recommendations regarding the process. DISCUSSION Hydraulic fracturing process raises various issues both legally and environmentally. The water contamination by the chemicals used during the fracking process has brought out legal issues of strict liability where individuals have asserted harm from such contaminated water. In a Pennsylvanian case of Fiorentino v. Cabot Oil & Gas Corp., No. 09-cv-2284 (M.D. Pa. November 15, 2010), the plaintiff seeks action to be taken against the oil and gas company. This follows the alleged contamination of the plaintiff’s water by methane and other toxins. The court refused to dismiss this case and hence opened a look into allowing plaintiff come up with a claim of strict liability against the hydraulic fracturing companies (U.S. ENVTL. PROT. AGENCY, 2009). The other legal issue presented by the hydraulic fracturing is who is to be held r esponsible in cases of harm occasioned by the process. From the Fiorentino v. Cabot Oil & Gas Corp.case, it appears that it becomes an issue to the courts to determine the liability of the fracturing company and hence seeks to follow up and develop a rule suitable for this situation. Strict liability seems to have been inapplicable in such issues from the way the defendant presents his case in these proceedings. While various states are embracing this process in gas and oil extraction, other states have banned it and hence are an illegal process. However, some states have left the discretion to the local leaders to decide whether the process should be permitted or not. Permitting such a process is done after various considerations depending on the local leaders take on the public health and safety in case of a flag to engage in the extraction process. The environmental concerns so raised by the hydraulic process are vast and alarming. First, there is a threat of contamination of the underground water brought about by the spillage of the gases and oil extracted. Most of this underground water is a source of drinking water to many, both human and the animals. In an event of contamination of the drinking water then the vast population is affected. Secondly the use of a lot of water from the ground water and the surface water during drilling and the hydraulic fracturing brings a lot of stress to these water suppliers. The drilling and fracturing